Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å

The local lipid environment is known to affect the structure, stability and intercellular channel activity of gap junctions, however, the molecular basis for these effects remains unknown. Here authors report the CryoEM structure of Cx46/50 lipid-embedded channels, by which they reveal a lipid-induc...

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Auteurs principaux: Jonathan A. Flores, Bassam G. Haddad, Kimberly A. Dolan, Janette B. Myers, Craig C. Yoshioka, Jeremy Copperman, Daniel M. Zuckerman, Steve L. Reichow
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/cc52d1281bb34d24bc69004c93903dd8
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