Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å

The local lipid environment is known to affect the structure, stability and intercellular channel activity of gap junctions, however, the molecular basis for these effects remains unknown. Here authors report the CryoEM structure of Cx46/50 lipid-embedded channels, by which they reveal a lipid-induc...

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Autores principales:	Jonathan A. Flores, Bassam G. Haddad, Kimberly A. Dolan, Janette B. Myers, Craig C. Yoshioka, Jeremy Copperman, Daniel M. Zuckerman, Steve L. Reichow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc52d1281bb34d24bc69004c93903dd8
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spelling	oai:doaj.org-article:cc52d1281bb34d24bc69004c93903dd82021-12-02T15:09:18ZConnexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å10.1038/s41467-020-18120-52041-1723https://doaj.org/article/cc52d1281bb34d24bc69004c93903dd82020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18120-5https://doaj.org/toc/2041-1723The local lipid environment is known to affect the structure, stability and intercellular channel activity of gap junctions, however, the molecular basis for these effects remains unknown. Here authors report the CryoEM structure of Cx46/50 lipid-embedded channels, by which they reveal a lipid-induced stabilization to the channel.Jonathan A. FloresBassam G. HaddadKimberly A. DolanJanette B. MyersCraig C. YoshiokaJeremy CoppermanDaniel M. ZuckermanSteve L. ReichowNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan A. Flores Bassam G. Haddad Kimberly A. Dolan Janette B. Myers Craig C. Yoshioka Jeremy Copperman Daniel M. Zuckerman Steve L. Reichow Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
description	The local lipid environment is known to affect the structure, stability and intercellular channel activity of gap junctions, however, the molecular basis for these effects remains unknown. Here authors report the CryoEM structure of Cx46/50 lipid-embedded channels, by which they reveal a lipid-induced stabilization to the channel.
format	article
author	Jonathan A. Flores Bassam G. Haddad Kimberly A. Dolan Janette B. Myers Craig C. Yoshioka Jeremy Copperman Daniel M. Zuckerman Steve L. Reichow
author_facet	Jonathan A. Flores Bassam G. Haddad Kimberly A. Dolan Janette B. Myers Craig C. Yoshioka Jeremy Copperman Daniel M. Zuckerman Steve L. Reichow
author_sort	Jonathan A. Flores
title	Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
title_short	Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
title_full	Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
title_fullStr	Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
title_full_unstemmed	Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
title_sort	connexin-46/50 in a dynamic lipid environment resolved by cryoem at 1.9 å
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc52d1281bb34d24bc69004c93903dd8
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Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å

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