Selective inhibition of the kinase DYRK1A by targeting its folding process

Kinase inhibitors are important drugs and usually target the ATP binding pocket of kinases. Here, Kii et al.report a completely new type of kinase inhibitor that specifically targets the protein folding intermediate state, but not the mature form, of the protein kinase DYRK1A.

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Autores principales:	Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc58fcf33b4145468837fef116260032
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spelling	oai:doaj.org-article:cc58fcf33b4145468837fef1162600322021-12-02T15:34:32ZSelective inhibition of the kinase DYRK1A by targeting its folding process10.1038/ncomms113912041-1723https://doaj.org/article/cc58fcf33b4145468837fef1162600322016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11391https://doaj.org/toc/2041-1723Kinase inhibitors are important drugs and usually target the ATP binding pocket of kinases. Here, Kii et al.report a completely new type of kinase inhibitor that specifically targets the protein folding intermediate state, but not the mature form, of the protein kinase DYRK1A.Isao KiiYuto SumidaToshiyasu GotoRie SonamotoYukiko OkunoSuguru YoshidaTomoe Kato-SumidaYuka KoikeMinako AbeYosuke NonakaTeikichi IkuraNobutoshi ItoHiroshi ShibuyaTakamitsu HosoyaMasatoshi HagiwaraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isao Kii Yuto Sumida Toshiyasu Goto Rie Sonamoto Yukiko Okuno Suguru Yoshida Tomoe Kato-Sumida Yuka Koike Minako Abe Yosuke Nonaka Teikichi Ikura Nobutoshi Ito Hiroshi Shibuya Takamitsu Hosoya Masatoshi Hagiwara Selective inhibition of the kinase DYRK1A by targeting its folding process
description	Kinase inhibitors are important drugs and usually target the ATP binding pocket of kinases. Here, Kii et al.report a completely new type of kinase inhibitor that specifically targets the protein folding intermediate state, but not the mature form, of the protein kinase DYRK1A.
format	article
author	Isao Kii Yuto Sumida Toshiyasu Goto Rie Sonamoto Yukiko Okuno Suguru Yoshida Tomoe Kato-Sumida Yuka Koike Minako Abe Yosuke Nonaka Teikichi Ikura Nobutoshi Ito Hiroshi Shibuya Takamitsu Hosoya Masatoshi Hagiwara
author_facet	Isao Kii Yuto Sumida Toshiyasu Goto Rie Sonamoto Yukiko Okuno Suguru Yoshida Tomoe Kato-Sumida Yuka Koike Minako Abe Yosuke Nonaka Teikichi Ikura Nobutoshi Ito Hiroshi Shibuya Takamitsu Hosoya Masatoshi Hagiwara
author_sort	Isao Kii
title	Selective inhibition of the kinase DYRK1A by targeting its folding process
title_short	Selective inhibition of the kinase DYRK1A by targeting its folding process
title_full	Selective inhibition of the kinase DYRK1A by targeting its folding process
title_fullStr	Selective inhibition of the kinase DYRK1A by targeting its folding process
title_full_unstemmed	Selective inhibition of the kinase DYRK1A by targeting its folding process
title_sort	selective inhibition of the kinase dyrk1a by targeting its folding process
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cc58fcf33b4145468837fef116260032
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Selective inhibition of the kinase DYRK1A by targeting its folding process

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