Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C

Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C

Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobul...

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Main Authors: Aleksandra Bilska, Monika Kusio-Kobiałka, Paweł S. Krawczyk, Olga Gewartowska, Bartosz Tarkowski, Kamil Kobyłecki, Dominika Nowis, Jakub Golab, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski, Seweryn Mroczek
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/cc7369751a0649a8ac0d65c96e3806d5
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Summary:Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobulins.

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