Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain

The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies surface expression and trafficking.

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Bibliographic Details
Main Authors: Gui-Fang Duan, Yaxin Ye, Sha Xu, Wucheng Tao, Shiping Zhao, Tengchuan Jin, Roger A. Nicoll, Yun Stone Shi, Nengyin Sheng
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/cc781a02cb3d418899baa57e51f71444
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