Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain

The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies surface expression and trafficking.

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Autores principales:	Gui-Fang Duan, Yaxin Ye, Sha Xu, Wucheng Tao, Shiping Zhao, Tengchuan Jin, Roger A. Nicoll, Yun Stone Shi, Nengyin Sheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc781a02cb3d418899baa57e51f71444
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spelling	oai:doaj.org-article:cc781a02cb3d418899baa57e51f714442021-12-02T14:41:06ZSignal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain10.1038/s41467-018-07403-72041-1723https://doaj.org/article/cc781a02cb3d418899baa57e51f714442018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07403-7https://doaj.org/toc/2041-1723The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies surface expression and trafficking.Gui-Fang DuanYaxin YeSha XuWucheng TaoShiping ZhaoTengchuan JinRoger A. NicollYun Stone ShiNengyin ShengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gui-Fang Duan Yaxin Ye Sha Xu Wucheng Tao Shiping Zhao Tengchuan Jin Roger A. Nicoll Yun Stone Shi Nengyin Sheng Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
description	The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies surface expression and trafficking.
format	article
author	Gui-Fang Duan Yaxin Ye Sha Xu Wucheng Tao Shiping Zhao Tengchuan Jin Roger A. Nicoll Yun Stone Shi Nengyin Sheng
author_facet	Gui-Fang Duan Yaxin Ye Sha Xu Wucheng Tao Shiping Zhao Tengchuan Jin Roger A. Nicoll Yun Stone Shi Nengyin Sheng
author_sort	Gui-Fang Duan
title	Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
title_short	Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
title_full	Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
title_fullStr	Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
title_full_unstemmed	Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
title_sort	signal peptide represses gluk1 surface and synaptic trafficking through binding to amino-terminal domain
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cc781a02cb3d418899baa57e51f71444
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Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain

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