MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here the authors find that protein phosphatase 1 and its regulatory subunit PNUTS controls MYC stability and its interaction with chromatin.

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Autores principales:	Dharmendra Dingar, William B. Tu, Diana Resetca, Corey Lourenco, Aaliya Tamachi, Jason De Melo, Kathleen E. Houlahan, Manpreet Kalkat, Pak-Kei Chan, Paul C. Boutros, Brian Raught, Linda Z. Penn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc8066c5d0d249efbc4b69b3a8efd7c8
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spelling	oai:doaj.org-article:cc8066c5d0d249efbc4b69b3a8efd7c82021-12-02T14:40:45ZMYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability10.1038/s41467-018-05660-02041-1723https://doaj.org/article/cc8066c5d0d249efbc4b69b3a8efd7c82018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05660-0https://doaj.org/toc/2041-1723Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here the authors find that protein phosphatase 1 and its regulatory subunit PNUTS controls MYC stability and its interaction with chromatin.Dharmendra DingarWilliam B. TuDiana ResetcaCorey LourencoAaliya TamachiJason De MeloKathleen E. HoulahanManpreet KalkatPak-Kei ChanPaul C. BoutrosBrian RaughtLinda Z. PennNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dharmendra Dingar William B. Tu Diana Resetca Corey Lourenco Aaliya Tamachi Jason De Melo Kathleen E. Houlahan Manpreet Kalkat Pak-Kei Chan Paul C. Boutros Brian Raught Linda Z. Penn MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
description	Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here the authors find that protein phosphatase 1 and its regulatory subunit PNUTS controls MYC stability and its interaction with chromatin.
format	article
author	Dharmendra Dingar William B. Tu Diana Resetca Corey Lourenco Aaliya Tamachi Jason De Melo Kathleen E. Houlahan Manpreet Kalkat Pak-Kei Chan Paul C. Boutros Brian Raught Linda Z. Penn
author_facet	Dharmendra Dingar William B. Tu Diana Resetca Corey Lourenco Aaliya Tamachi Jason De Melo Kathleen E. Houlahan Manpreet Kalkat Pak-Kei Chan Paul C. Boutros Brian Raught Linda Z. Penn
author_sort	Dharmendra Dingar
title	MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
title_short	MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
title_full	MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
title_fullStr	MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
title_full_unstemmed	MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
title_sort	myc dephosphorylation by the pp1/pnuts phosphatase complex regulates chromatin binding and protein stability
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cc8066c5d0d249efbc4b69b3a8efd7c8
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MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

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