Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit

It is unclear how some Drosophila neurons develop sex-specific neurites that contribute to dimorphic circuitries required for gendered behavior. The authors show that sex-specific cleavage by the E3 ubiquitin ligase Cullin1 and 26S proteasome of the pleiotropic BTB-ZF transcription factor Lola confe...

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Autores principales: Kosei Sato, Hiroki Ito, Atsushi Yokoyama, Gakuta Toba, Daisuke Yamamoto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ccf0c9251564483ca9374ee0dc2e6fab
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