Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit

It is unclear how some Drosophila neurons develop sex-specific neurites that contribute to dimorphic circuitries required for gendered behavior. The authors show that sex-specific cleavage by the E3 ubiquitin ligase Cullin1 and 26S proteasome of the pleiotropic BTB-ZF transcription factor Lola confe...

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Autores principales:	Kosei Sato, Hiroki Ito, Atsushi Yokoyama, Gakuta Toba, Daisuke Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccf0c9251564483ca9374ee0dc2e6fab
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spelling	oai:doaj.org-article:ccf0c9251564483ca9374ee0dc2e6fab2021-12-02T17:02:19ZPartial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit10.1038/s41467-018-08146-12041-1723https://doaj.org/article/ccf0c9251564483ca9374ee0dc2e6fab2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08146-1https://doaj.org/toc/2041-1723It is unclear how some Drosophila neurons develop sex-specific neurites that contribute to dimorphic circuitries required for gendered behavior. The authors show that sex-specific cleavage by the E3 ubiquitin ligase Cullin1 and 26S proteasome of the pleiotropic BTB-ZF transcription factor Lola confers its sexual fate-inducing ability in these neurons.Kosei SatoHiroki ItoAtsushi YokoyamaGakuta TobaDaisuke YamamotoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kosei Sato Hiroki Ito Atsushi Yokoyama Gakuta Toba Daisuke Yamamoto Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
description	It is unclear how some Drosophila neurons develop sex-specific neurites that contribute to dimorphic circuitries required for gendered behavior. The authors show that sex-specific cleavage by the E3 ubiquitin ligase Cullin1 and 26S proteasome of the pleiotropic BTB-ZF transcription factor Lola confers its sexual fate-inducing ability in these neurons.
format	article
author	Kosei Sato Hiroki Ito Atsushi Yokoyama Gakuta Toba Daisuke Yamamoto
author_facet	Kosei Sato Hiroki Ito Atsushi Yokoyama Gakuta Toba Daisuke Yamamoto
author_sort	Kosei Sato
title	Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
title_short	Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
title_full	Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
title_fullStr	Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
title_full_unstemmed	Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
title_sort	partial proteasomal degradation of lola triggers the male-to-female switch of a dimorphic courtship circuit
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ccf0c9251564483ca9374ee0dc2e6fab
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Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit

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