Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin

Abstract Queen health is crucial to colony survival of honeybees, since reproduction and colony growth rely solely on the queen. Queen failure is considered a relevant cause of colony losses, yet few data exist concerning effects of environmental stressors on queens. Here we demonstrate for the firs...

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Autores principales:	Annely Brandt, Katharina Grikscheit, Reinhold Siede, Robert Grosse, Marina Doris Meixner, Ralph Büchler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd4b75ab5f35483a9acc5309e27d21be
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spelling	oai:doaj.org-article:cd4b75ab5f35483a9acc5309e27d21be2021-12-02T16:06:11ZImmunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin10.1038/s41598-017-04734-12045-2322https://doaj.org/article/cd4b75ab5f35483a9acc5309e27d21be2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04734-1https://doaj.org/toc/2045-2322Abstract Queen health is crucial to colony survival of honeybees, since reproduction and colony growth rely solely on the queen. Queen failure is considered a relevant cause of colony losses, yet few data exist concerning effects of environmental stressors on queens. Here we demonstrate for the first time that exposure to field-realistic concentrations of neonicotinoid pesticides can severely affect the immunocompetence of queens of western honeybees (Apis mellifera L.). In young queens exposed to thiacloprid (200 µg/l or 2000 µg/l) or clothianidin (10 µg/l or 50 µg/l), the total hemocyte number and the proportion of active, differentiated hemocytes was significantly reduced. Moreover, functional aspects of the immune defence namely the wound healing/melanisation response, as well as the antimicrobial activity of the hemolymph were impaired. Our results demonstrate that neonicotinoid insecticides can negatively affect the immunocompetence of queens, possibly leading to an impaired disease resistance capacity.Annely BrandtKatharina GrikscheitReinhold SiedeRobert GrosseMarina Doris MeixnerRalph BüchlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annely Brandt Katharina Grikscheit Reinhold Siede Robert Grosse Marina Doris Meixner Ralph Büchler Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
description	Abstract Queen health is crucial to colony survival of honeybees, since reproduction and colony growth rely solely on the queen. Queen failure is considered a relevant cause of colony losses, yet few data exist concerning effects of environmental stressors on queens. Here we demonstrate for the first time that exposure to field-realistic concentrations of neonicotinoid pesticides can severely affect the immunocompetence of queens of western honeybees (Apis mellifera L.). In young queens exposed to thiacloprid (200 µg/l or 2000 µg/l) or clothianidin (10 µg/l or 50 µg/l), the total hemocyte number and the proportion of active, differentiated hemocytes was significantly reduced. Moreover, functional aspects of the immune defence namely the wound healing/melanisation response, as well as the antimicrobial activity of the hemolymph were impaired. Our results demonstrate that neonicotinoid insecticides can negatively affect the immunocompetence of queens, possibly leading to an impaired disease resistance capacity.
format	article
author	Annely Brandt Katharina Grikscheit Reinhold Siede Robert Grosse Marina Doris Meixner Ralph Büchler
author_facet	Annely Brandt Katharina Grikscheit Reinhold Siede Robert Grosse Marina Doris Meixner Ralph Büchler
author_sort	Annely Brandt
title	Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
title_short	Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
title_full	Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
title_fullStr	Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
title_full_unstemmed	Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
title_sort	immunosuppression in honeybee queens by the neonicotinoids thiacloprid and clothianidin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cd4b75ab5f35483a9acc5309e27d21be
work_keys_str_mv	AT annelybrandt immunosuppressioninhoneybeequeensbytheneonicotinoidsthiaclopridandclothianidin AT katharinagrikscheit immunosuppressioninhoneybeequeensbytheneonicotinoidsthiaclopridandclothianidin AT reinholdsiede immunosuppressioninhoneybeequeensbytheneonicotinoidsthiaclopridandclothianidin AT robertgrosse immunosuppressioninhoneybeequeensbytheneonicotinoidsthiaclopridandclothianidin AT marinadorismeixner immunosuppressioninhoneybeequeensbytheneonicotinoidsthiaclopridandclothianidin AT ralphbuchler immunosuppressioninhoneybeequeensbytheneonicotinoidsthiaclopridandclothianidin
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Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin

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