Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats.

Notch signaling is essential to the regulation of cell differentiation, and aberrant activation of this pathway is implicated in human fibrotic diseases, such as pulmonary, renal, and peritoneal fibrosis. However, the role of Notch signaling in hepatic fibrosis has not been fully investigated. In th...

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Auteurs principaux: Yixiong Chen, Shaoping Zheng, Dan Qi, Shaojiang Zheng, Junli Guo, Shuling Zhang, Zhihong Weng
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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R
Q
Accès en ligne:https://doaj.org/article/cd589a7ff140419dab8bec455b1642cb
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