DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

Abstract The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA). We and others have shown that the abnormal MMP13 gene expression in OA...

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Autores principales: Atsushi Takahashi, María C. de Andrés, Ko Hashimoto, Eiji Itoi, Miguel Otero, Mary B. Goldring, Richard O. C. Oreffo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cd76ae98337946548bf91121591784a3
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