High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated...
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Nature Portfolio
2020
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oai:doaj.org-article:cd7b2cc9b0fc4138b9abcb1d773ede392021-12-02T16:49:29ZHigh-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations10.1038/s41467-019-13885-w2041-1723https://doaj.org/article/cd7b2cc9b0fc4138b9abcb1d773ede392020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13885-whttps://doaj.org/toc/2041-1723In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.Yiqun ZhangFengju ChenNuno A. FonsecaYao HeMasashi FujitaHidewaki NakagawaZemin ZhangAlvis BrazmaPCAWG Transcriptome Working GroupPCAWG Structural Variation Working GroupChad J. CreightonPCAWG ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Yiqun Zhang Fengju Chen Nuno A. Fonseca Yao He Masashi Fujita Hidewaki Nakagawa Zemin Zhang Alvis Brazma PCAWG Transcriptome Working Group PCAWG Structural Variation Working Group Chad J. Creighton PCAWG Consortium High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations |
| description |
In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression. |
| format |
article |
| author |
Yiqun Zhang Fengju Chen Nuno A. Fonseca Yao He Masashi Fujita Hidewaki Nakagawa Zemin Zhang Alvis Brazma PCAWG Transcriptome Working Group PCAWG Structural Variation Working Group Chad J. Creighton PCAWG Consortium |
| author_facet |
Yiqun Zhang Fengju Chen Nuno A. Fonseca Yao He Masashi Fujita Hidewaki Nakagawa Zemin Zhang Alvis Brazma PCAWG Transcriptome Working Group PCAWG Structural Variation Working Group Chad J. Creighton PCAWG Consortium |
| author_sort |
Yiqun Zhang |
| title |
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations |
| title_short |
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations |
| title_full |
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations |
| title_fullStr |
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations |
| title_full_unstemmed |
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations |
| title_sort |
high-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/cd7b2cc9b0fc4138b9abcb1d773ede39 |
| work_keys_str_mv |
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