Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes

Anteroposterior axis extension during gastrulation is dynamically coordinated, but how this is regulated at a molecular level is unclear. Here, the authors show in zebrafish that the chromatin factor Gon4l, encoded by ugly duckling, coordinates axis extension by modulating EpCAM and Integrinα3b expr...

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Autores principales:	Margot L. K. Williams, Atsushi Sawada, Terin Budine, Chunyue Yin, Paul Gontarz, Lilianna Solnica-Krezel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd8d2c162cea4451acb9c892aace8007
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spelling	oai:doaj.org-article:cd8d2c162cea4451acb9c892aace80072021-12-02T15:34:19ZGon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes10.1038/s41467-018-03715-w2041-1723https://doaj.org/article/cd8d2c162cea4451acb9c892aace80072018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03715-whttps://doaj.org/toc/2041-1723Anteroposterior axis extension during gastrulation is dynamically coordinated, but how this is regulated at a molecular level is unclear. Here, the authors show in zebrafish that the chromatin factor Gon4l, encoded by ugly duckling, coordinates axis extension by modulating EpCAM and Integrinα3b expression.Margot L. K. WilliamsAtsushi SawadaTerin BudineChunyue YinPaul GontarzLilianna Solnica-KrezelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Margot L. K. Williams Atsushi Sawada Terin Budine Chunyue Yin Paul Gontarz Lilianna Solnica-Krezel Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
description	Anteroposterior axis extension during gastrulation is dynamically coordinated, but how this is regulated at a molecular level is unclear. Here, the authors show in zebrafish that the chromatin factor Gon4l, encoded by ugly duckling, coordinates axis extension by modulating EpCAM and Integrinα3b expression.
format	article
author	Margot L. K. Williams Atsushi Sawada Terin Budine Chunyue Yin Paul Gontarz Lilianna Solnica-Krezel
author_facet	Margot L. K. Williams Atsushi Sawada Terin Budine Chunyue Yin Paul Gontarz Lilianna Solnica-Krezel
author_sort	Margot L. K. Williams
title	Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
title_short	Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
title_full	Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
title_fullStr	Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
title_full_unstemmed	Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
title_sort	gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cd8d2c162cea4451acb9c892aace8007
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_version_	1718386865506091008

Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes

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