Impact of comorbid asthma on severity of coronavirus disease (COVID-19)

Abstract The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Kor...

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Main Authors:	Sang Chul Lee, Kang Ju Son, Chang Hoon Han, Ji Ye Jung, Seon Cheol Park
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/cd9413f1e8b54c5a898645a7805d99a7
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spelling	oai:doaj.org-article:cd9413f1e8b54c5a898645a7805d99a72021-12-02T15:11:53ZImpact of comorbid asthma on severity of coronavirus disease (COVID-19)10.1038/s41598-020-77791-82045-2322https://doaj.org/article/cd9413f1e8b54c5a898645a7805d99a72020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77791-8https://doaj.org/toc/2045-2322Abstract The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Korean Health Insurance Review and Assessment COVID-19 database for this nationwide retrospective cohort study. Among these, 686 patients with asthma were assessed by their severities and evaluated by the clinical outcome of COVID-19 compared to patients without asthma. Of 7272 adult COVID-19 patients, 686 with asthma and 6586 without asthma were compared. Asthma was not a significant risk factor for respiratory failure or mortality among all COVID-19 patients (odds ratio [OR] = 0.99, P = 0.997 and OR = 1.06, P = 0.759) after adjusting for age, sex, and the Charlson comorbidity score. However, a history of acute exacerbation (OR = 2.63, P = 0.043) was significant risk factors for death among COVID-19 patients with asthma. Asthma is not a risk factor for poor prognosis of COVID-19. However, asthma patients who had any experience of acute exacerbation in the previous year before COVID-19 showed higher COVID-19-related mortality, especially in case of old age and male sex.Sang Chul LeeKang Ju SonChang Hoon HanJi Ye JungSeon Cheol ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang Chul Lee Kang Ju Son Chang Hoon Han Ji Ye Jung Seon Cheol Park Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
description	Abstract The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Korean Health Insurance Review and Assessment COVID-19 database for this nationwide retrospective cohort study. Among these, 686 patients with asthma were assessed by their severities and evaluated by the clinical outcome of COVID-19 compared to patients without asthma. Of 7272 adult COVID-19 patients, 686 with asthma and 6586 without asthma were compared. Asthma was not a significant risk factor for respiratory failure or mortality among all COVID-19 patients (odds ratio [OR] = 0.99, P = 0.997 and OR = 1.06, P = 0.759) after adjusting for age, sex, and the Charlson comorbidity score. However, a history of acute exacerbation (OR = 2.63, P = 0.043) was significant risk factors for death among COVID-19 patients with asthma. Asthma is not a risk factor for poor prognosis of COVID-19. However, asthma patients who had any experience of acute exacerbation in the previous year before COVID-19 showed higher COVID-19-related mortality, especially in case of old age and male sex.
format	article
author	Sang Chul Lee Kang Ju Son Chang Hoon Han Ji Ye Jung Seon Cheol Park
author_facet	Sang Chul Lee Kang Ju Son Chang Hoon Han Ji Ye Jung Seon Cheol Park
author_sort	Sang Chul Lee
title	Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
title_short	Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
title_full	Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
title_fullStr	Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
title_full_unstemmed	Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
title_sort	impact of comorbid asthma on severity of coronavirus disease (covid-19)
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cd9413f1e8b54c5a898645a7805d99a7
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Impact of comorbid asthma on severity of coronavirus disease (COVID-19)

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