Computational insights into the inhibitory mechanism of human AKT1 by an orally active inhibitor, MK-2206.
The AKT signaling pathway has been identified as an important target for cancer therapy. Among small-molecule inhibitors of AKT that have shown tremendous potential in inhibiting cancer, MK-2206 is a highly potent, selective and orally active allosteric inhibitor. Promising preclinical anticancer re...
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2014
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/cdbecee0d83e46b68810817fb3f3c93b |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|