Structural modularity of the XIST ribonucleoprotein complex

The long noncoding RNA XIST plays a central role in sex-specific gene expression in humans by silencing one of two X chromosomes in female cells. Here the authors show that higher order secondary structure creates the modular domain structure of XIST ribonucleoprotein complex and spatial separation...

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Autores principales:	Zhipeng Lu, Jimmy K. Guo, Yuning Wei, Diana R. Dou, Brian Zarnegar, Qing Ma, Rui Li, Yang Zhao, Fan Liu, Hani Choudhry, Paul A. Khavari, Howard Y. Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce192c166d4848879fbe0c187c228701
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spelling	oai:doaj.org-article:ce192c166d4848879fbe0c187c2287012021-12-02T16:50:03ZStructural modularity of the XIST ribonucleoprotein complex10.1038/s41467-020-20040-32041-1723https://doaj.org/article/ce192c166d4848879fbe0c187c2287012020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20040-3https://doaj.org/toc/2041-1723The long noncoding RNA XIST plays a central role in sex-specific gene expression in humans by silencing one of two X chromosomes in female cells. Here the authors show that higher order secondary structure creates the modular domain structure of XIST ribonucleoprotein complex and spatial separation of functions.Zhipeng LuJimmy K. GuoYuning WeiDiana R. DouBrian ZarnegarQing MaRui LiYang ZhaoFan LiuHani ChoudhryPaul A. KhavariHoward Y. ChangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhipeng Lu Jimmy K. Guo Yuning Wei Diana R. Dou Brian Zarnegar Qing Ma Rui Li Yang Zhao Fan Liu Hani Choudhry Paul A. Khavari Howard Y. Chang Structural modularity of the XIST ribonucleoprotein complex
description	The long noncoding RNA XIST plays a central role in sex-specific gene expression in humans by silencing one of two X chromosomes in female cells. Here the authors show that higher order secondary structure creates the modular domain structure of XIST ribonucleoprotein complex and spatial separation of functions.
format	article
author	Zhipeng Lu Jimmy K. Guo Yuning Wei Diana R. Dou Brian Zarnegar Qing Ma Rui Li Yang Zhao Fan Liu Hani Choudhry Paul A. Khavari Howard Y. Chang
author_facet	Zhipeng Lu Jimmy K. Guo Yuning Wei Diana R. Dou Brian Zarnegar Qing Ma Rui Li Yang Zhao Fan Liu Hani Choudhry Paul A. Khavari Howard Y. Chang
author_sort	Zhipeng Lu
title	Structural modularity of the XIST ribonucleoprotein complex
title_short	Structural modularity of the XIST ribonucleoprotein complex
title_full	Structural modularity of the XIST ribonucleoprotein complex
title_fullStr	Structural modularity of the XIST ribonucleoprotein complex
title_full_unstemmed	Structural modularity of the XIST ribonucleoprotein complex
title_sort	structural modularity of the xist ribonucleoprotein complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ce192c166d4848879fbe0c187c228701
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Structural modularity of the XIST ribonucleoprotein complex

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