Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Targeting the ubiquitin proteasome system to modulate protein homeostasis using small molecules has promising therapeutic potential. Here the authors describe Homo-PROTACS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation.

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Autores principales:	Chiara Maniaci, Scott J. Hughes, Andrea Testa, Wenzhang Chen, Douglas J. Lamont, Sonia Rocha, Dario R. Alessi, Roberto Romeo, Alessio Ciulli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce1eb8bbc3b24cf8a56b68d61eacff1e
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spelling	oai:doaj.org-article:ce1eb8bbc3b24cf8a56b68d61eacff1e2021-12-02T14:40:59ZHomo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation10.1038/s41467-017-00954-12041-1723https://doaj.org/article/ce1eb8bbc3b24cf8a56b68d61eacff1e2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00954-1https://doaj.org/toc/2041-1723Targeting the ubiquitin proteasome system to modulate protein homeostasis using small molecules has promising therapeutic potential. Here the authors describe Homo-PROTACS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation.Chiara ManiaciScott J. HughesAndrea TestaWenzhang ChenDouglas J. LamontSonia RochaDario R. AlessiRoberto RomeoAlessio CiulliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiara Maniaci Scott J. Hughes Andrea Testa Wenzhang Chen Douglas J. Lamont Sonia Rocha Dario R. Alessi Roberto Romeo Alessio Ciulli Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
description	Targeting the ubiquitin proteasome system to modulate protein homeostasis using small molecules has promising therapeutic potential. Here the authors describe Homo-PROTACS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation.
format	article
author	Chiara Maniaci Scott J. Hughes Andrea Testa Wenzhang Chen Douglas J. Lamont Sonia Rocha Dario R. Alessi Roberto Romeo Alessio Ciulli
author_facet	Chiara Maniaci Scott J. Hughes Andrea Testa Wenzhang Chen Douglas J. Lamont Sonia Rocha Dario R. Alessi Roberto Romeo Alessio Ciulli
author_sort	Chiara Maniaci
title	Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
title_short	Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
title_full	Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
title_fullStr	Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
title_full_unstemmed	Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
title_sort	homo-protacs: bivalent small-molecule dimerizers of the vhl e3 ubiquitin ligase to induce self-degradation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ce1eb8bbc3b24cf8a56b68d61eacff1e
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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

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