Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

Calreticulin del52 and ins5 mutations induce two phenotypically distinct myeloproliferative neoplasms in patients. Here the authors show that modeling these mutations in knock-in mice recapitulate the two diseases and highlight how they impact the different hematopoietic compartments.

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Autores principales: Camélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller, Philippe Rameau, Laure Touchard, Patrick Gonin, Stefan N. Constantinescu, Hana Raslova, Jean-Luc Villeval, William Vainchenker, Isabelle Plo, Caroline Marty
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ce23c15ed9354d4c9eb59d46f3b21b44
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