Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN
Calreticulin del52 and ins5 mutations induce two phenotypically distinct myeloproliferative neoplasms in patients. Here the authors show that modeling these mutations in knock-in mice recapitulate the two diseases and highlight how they impact the different hematopoietic compartments.
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Nature Portfolio
2020
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oai:doaj.org-article:ce23c15ed9354d4c9eb59d46f3b21b442021-12-02T18:51:37ZCalreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN10.1038/s41467-020-18691-32041-1723https://doaj.org/article/ce23c15ed9354d4c9eb59d46f3b21b442020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18691-3https://doaj.org/toc/2041-1723Calreticulin del52 and ins5 mutations induce two phenotypically distinct myeloproliferative neoplasms in patients. Here the authors show that modeling these mutations in knock-in mice recapitulate the two diseases and highlight how they impact the different hematopoietic compartments.Camélia BenlabiodMaira da Costa CacemiroAudrey NédélecValérie EdmondDelphine MullerPhilippe RameauLaure TouchardPatrick GoninStefan N. ConstantinescuHana RaslovaJean-Luc VillevalWilliam VainchenkerIsabelle PloCaroline MartyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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Science Q |
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Science Q Camélia Benlabiod Maira da Costa Cacemiro Audrey Nédélec Valérie Edmond Delphine Muller Philippe Rameau Laure Touchard Patrick Gonin Stefan N. Constantinescu Hana Raslova Jean-Luc Villeval William Vainchenker Isabelle Plo Caroline Marty Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN |
| description |
Calreticulin del52 and ins5 mutations induce two phenotypically distinct myeloproliferative neoplasms in patients. Here the authors show that modeling these mutations in knock-in mice recapitulate the two diseases and highlight how they impact the different hematopoietic compartments. |
| format |
article |
| author |
Camélia Benlabiod Maira da Costa Cacemiro Audrey Nédélec Valérie Edmond Delphine Muller Philippe Rameau Laure Touchard Patrick Gonin Stefan N. Constantinescu Hana Raslova Jean-Luc Villeval William Vainchenker Isabelle Plo Caroline Marty |
| author_facet |
Camélia Benlabiod Maira da Costa Cacemiro Audrey Nédélec Valérie Edmond Delphine Muller Philippe Rameau Laure Touchard Patrick Gonin Stefan N. Constantinescu Hana Raslova Jean-Luc Villeval William Vainchenker Isabelle Plo Caroline Marty |
| author_sort |
Camélia Benlabiod |
| title |
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN |
| title_short |
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN |
| title_full |
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN |
| title_fullStr |
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN |
| title_full_unstemmed |
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN |
| title_sort |
calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with mpn |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ce23c15ed9354d4c9eb59d46f3b21b44 |
| work_keys_str_mv |
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| _version_ |
1718377412758077440 |