Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

IL11 contributes to the development of non-alcoholic steatohepatitis (NASH) through incompletely understood mechanisms. Here, the authors report that lipotoxicity-driven autocrine IL11 activity underlies hepatocyte metabolic dysfunction and death via a NOX4/ERK-mediated mechanism while paracrine IL1...

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Autores principales: Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K. Singh, Sonia P. Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M. Yen, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ce2b5ee017d5453ea86274564e8eb24f
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spelling oai:doaj.org-article:ce2b5ee017d5453ea86274564e8eb24f2021-12-02T11:45:56ZHepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH10.1038/s41467-020-20303-z2041-1723https://doaj.org/article/ce2b5ee017d5453ea86274564e8eb24f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20303-zhttps://doaj.org/toc/2041-1723IL11 contributes to the development of non-alcoholic steatohepatitis (NASH) through incompletely understood mechanisms. Here, the authors report that lipotoxicity-driven autocrine IL11 activity underlies hepatocyte metabolic dysfunction and death via a NOX4/ERK-mediated mechanism while paracrine IL11 activity stimulates hepatic stellate cells contributing to fibrosis and inflammation in the context of NASH.Jinrui DongSivakumar ViswanathanEleonora AdamiBrijesh K. SinghSonia P. ChothaniBenjamin NgWei Wen LimJin ZhouMadhulika TripathiNicole S. J. KoShamini G. ShekeranJessie TanSze Yun LimMao WangPei Min LioPaul M. YenSebastian SchaferStuart A. CookAnissa A. WidjajaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jinrui Dong
Sivakumar Viswanathan
Eleonora Adami
Brijesh K. Singh
Sonia P. Chothani
Benjamin Ng
Wei Wen Lim
Jin Zhou
Madhulika Tripathi
Nicole S. J. Ko
Shamini G. Shekeran
Jessie Tan
Sze Yun Lim
Mao Wang
Pei Min Lio
Paul M. Yen
Sebastian Schafer
Stuart A. Cook
Anissa A. Widjaja
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
description IL11 contributes to the development of non-alcoholic steatohepatitis (NASH) through incompletely understood mechanisms. Here, the authors report that lipotoxicity-driven autocrine IL11 activity underlies hepatocyte metabolic dysfunction and death via a NOX4/ERK-mediated mechanism while paracrine IL11 activity stimulates hepatic stellate cells contributing to fibrosis and inflammation in the context of NASH.
format article
author Jinrui Dong
Sivakumar Viswanathan
Eleonora Adami
Brijesh K. Singh
Sonia P. Chothani
Benjamin Ng
Wei Wen Lim
Jin Zhou
Madhulika Tripathi
Nicole S. J. Ko
Shamini G. Shekeran
Jessie Tan
Sze Yun Lim
Mao Wang
Pei Min Lio
Paul M. Yen
Sebastian Schafer
Stuart A. Cook
Anissa A. Widjaja
author_facet Jinrui Dong
Sivakumar Viswanathan
Eleonora Adami
Brijesh K. Singh
Sonia P. Chothani
Benjamin Ng
Wei Wen Lim
Jin Zhou
Madhulika Tripathi
Nicole S. J. Ko
Shamini G. Shekeran
Jessie Tan
Sze Yun Lim
Mao Wang
Pei Min Lio
Paul M. Yen
Sebastian Schafer
Stuart A. Cook
Anissa A. Widjaja
author_sort Jinrui Dong
title Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
title_short Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
title_full Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
title_fullStr Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
title_full_unstemmed Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
title_sort hepatocyte-specific il11 cis-signaling drives lipotoxicity and underlies the transition from nafld to nash
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ce2b5ee017d5453ea86274564e8eb24f
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