ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity

Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adarexpression impairs normal waking in flies.

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Autores principales: J. E. Robinson, J. Paluch, D. K. Dickman, W. J. Joiner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/ce31aae827ab426bb26dbf8945633928
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