ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity

Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adarexpression impairs normal waking in flies.

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Autores principales:	J. E. Robinson, J. Paluch, D. K. Dickman, W. J. Joiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce31aae827ab426bb26dbf8945633928
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spelling	oai:doaj.org-article:ce31aae827ab426bb26dbf89456339282021-12-02T15:35:24ZADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity10.1038/ncomms105122041-1723https://doaj.org/article/ce31aae827ab426bb26dbf89456339282016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10512https://doaj.org/toc/2041-1723Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adarexpression impairs normal waking in flies.J. E. RobinsonJ. PaluchD. K. DickmanW. J. JoinerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. E. Robinson J. Paluch D. K. Dickman W. J. Joiner ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
description	Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adarexpression impairs normal waking in flies.
format	article
author	J. E. Robinson J. Paluch D. K. Dickman W. J. Joiner
author_facet	J. E. Robinson J. Paluch D. K. Dickman W. J. Joiner
author_sort	J. E. Robinson
title	ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
title_short	ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
title_full	ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
title_fullStr	ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
title_full_unstemmed	ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
title_sort	adar-mediated rna editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ce31aae827ab426bb26dbf8945633928
work_keys_str_mv	AT jerobinson adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity AT jpaluch adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity AT dkdickman adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity AT wjjoiner adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity
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ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity

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