Calcium Ion Induced Structural Changes Promote Dimerization of Secretagogin, Which Is Required for Its Insulin Secretory Function

Abstract Secretagogin (SCGN), a hexa EF-hand calcium binding protein, plays key roles in insulin secretion in pancreatic β-cells. It is not yet understood how the binding of Ca2+ to human SCGN (hSCGN) promotes secretion. Here we have addressed this question, using mass spectrometry combined with a d...

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Autores principales: Jae-Jin Lee, Seo-Yun Yang, Jimin Park, James E. Ferrell, Dong-Hae Shin, Kong-Joo Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ce36b1a0499a4abe9aeb1be8098e29ca
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