Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.

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Autores principales: Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen, Poul Nissen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ce38a48876bc4d9fb74081c34943de76
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spelling oai:doaj.org-article:ce38a48876bc4d9fb74081c34943de762021-12-02T16:49:54ZDimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases10.1038/s41467-018-06787-w2041-1723https://doaj.org/article/ce38a48876bc4d9fb74081c34943de762018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06787-whttps://doaj.org/toc/2041-1723Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.Jacob Lauwring AndersenBorbala GesserErik Daa FunderChristine Juul Fælled NielsenHelle Gotfred-RasmussenMads Kirchheiner RasmussenRachel TothKurt Vesterager GothelfJ. Simon C. ArthurLars IversenPoul NissenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jacob Lauwring Andersen
Borbala Gesser
Erik Daa Funder
Christine Juul Fælled Nielsen
Helle Gotfred-Rasmussen
Mads Kirchheiner Rasmussen
Rachel Toth
Kurt Vesterager Gothelf
J. Simon C. Arthur
Lars Iversen
Poul Nissen
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
description Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.
format article
author Jacob Lauwring Andersen
Borbala Gesser
Erik Daa Funder
Christine Juul Fælled Nielsen
Helle Gotfred-Rasmussen
Mads Kirchheiner Rasmussen
Rachel Toth
Kurt Vesterager Gothelf
J. Simon C. Arthur
Lars Iversen
Poul Nissen
author_facet Jacob Lauwring Andersen
Borbala Gesser
Erik Daa Funder
Christine Juul Fælled Nielsen
Helle Gotfred-Rasmussen
Mads Kirchheiner Rasmussen
Rachel Toth
Kurt Vesterager Gothelf
J. Simon C. Arthur
Lars Iversen
Poul Nissen
author_sort Jacob Lauwring Andersen
title Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
title_short Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
title_full Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
title_fullStr Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
title_full_unstemmed Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
title_sort dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal s6 kinases
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ce38a48876bc4d9fb74081c34943de76
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AT erikdaafunder dimethylfumarateisanallostericcovalentinhibitorofthep90ribosomals6kinases
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