CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main med...
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81 |
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oai:doaj.org-article:ce7f282daf59489b9f1d9368f3849b812021-12-02T19:17:06ZCD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells10.1038/s41467-021-26091-42041-1723https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b812021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26091-4https://doaj.org/toc/2041-1723Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main mediator for related alterations in Treg activity and tumor outcome.Myung-Chul KimNicholas BorcherdingKawther K. AhmedAndrew P. VoigtAjaykumar VishwakarmaRyan KolbPaige N. KluzGaurav PandeyUmasankar DeTheodore DrashanskyEric Y. HelmXin ZhangKatherine N. Gibson-CorleyJulia Klesney-TaitYuwen ZhuJinglu LuJinsong LuXian HuangHongrui XiangJinke ChengDongyang WangZheng WangJian TangJiajia HuZhengting WangHua LiuMingjia LiHaoyang ZhuangDorina AvramDaohong ZhouRhonda BacherSong Guo ZhengXuefeng WuYousef ZakhariaWeizhou ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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Science Q Myung-Chul Kim Nicholas Borcherding Kawther K. Ahmed Andrew P. Voigt Ajaykumar Vishwakarma Ryan Kolb Paige N. Kluz Gaurav Pandey Umasankar De Theodore Drashansky Eric Y. Helm Xin Zhang Katherine N. Gibson-Corley Julia Klesney-Tait Yuwen Zhu Jinglu Lu Jinsong Lu Xian Huang Hongrui Xiang Jinke Cheng Dongyang Wang Zheng Wang Jian Tang Jiajia Hu Zhengting Wang Hua Liu Mingjia Li Haoyang Zhuang Dorina Avram Daohong Zhou Rhonda Bacher Song Guo Zheng Xuefeng Wu Yousef Zakharia Weizhou Zhang CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells |
| description |
Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main mediator for related alterations in Treg activity and tumor outcome. |
| format |
article |
| author |
Myung-Chul Kim Nicholas Borcherding Kawther K. Ahmed Andrew P. Voigt Ajaykumar Vishwakarma Ryan Kolb Paige N. Kluz Gaurav Pandey Umasankar De Theodore Drashansky Eric Y. Helm Xin Zhang Katherine N. Gibson-Corley Julia Klesney-Tait Yuwen Zhu Jinglu Lu Jinsong Lu Xian Huang Hongrui Xiang Jinke Cheng Dongyang Wang Zheng Wang Jian Tang Jiajia Hu Zhengting Wang Hua Liu Mingjia Li Haoyang Zhuang Dorina Avram Daohong Zhou Rhonda Bacher Song Guo Zheng Xuefeng Wu Yousef Zakharia Weizhou Zhang |
| author_facet |
Myung-Chul Kim Nicholas Borcherding Kawther K. Ahmed Andrew P. Voigt Ajaykumar Vishwakarma Ryan Kolb Paige N. Kluz Gaurav Pandey Umasankar De Theodore Drashansky Eric Y. Helm Xin Zhang Katherine N. Gibson-Corley Julia Klesney-Tait Yuwen Zhu Jinglu Lu Jinsong Lu Xian Huang Hongrui Xiang Jinke Cheng Dongyang Wang Zheng Wang Jian Tang Jiajia Hu Zhengting Wang Hua Liu Mingjia Li Haoyang Zhuang Dorina Avram Daohong Zhou Rhonda Bacher Song Guo Zheng Xuefeng Wu Yousef Zakharia Weizhou Zhang |
| author_sort |
Myung-Chul Kim |
| title |
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells |
| title_short |
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells |
| title_full |
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells |
| title_fullStr |
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells |
| title_full_unstemmed |
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells |
| title_sort |
cd177 modulates the function and homeostasis of tumor-infiltrating regulatory t cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81 |
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1718376938869882880 |