SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

ABSTRACT Recent evidence shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sensitive to interferons (IFNs). However, the most effective types of IFNs and the underlying antiviral effectors remain to be defined. Here, we show that zinc finger antiviral protein (ZAP), which pr...

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Détails bibliographiques
Auteurs principaux: Rayhane Nchioua, Dorota Kmiec, Janis A. Müller, Carina Conzelmann, Rüdiger Groß, Chad M. Swanson, Stuart J. D. Neil, Steffen Stenger, Daniel Sauter, Jan Münch, Konstantin M. J. Sparrer, Frank Kirchhoff
Format: article
Langue:EN
Publié: American Society for Microbiology 2020
Sujets:
COVID-19
CpG suppression
SARS-CoV-2
ZAP
evolution
interferon
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/ce8641cdf3aa423a894bfbb5ce1d791c
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https://doaj.org/article/ce8641cdf3aa423a894bfbb5ce1d791c

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