Time to revisit the endpoint dilution assay and to replace the TCID50 as a measure of a virus sample's infection concentration.

The endpoint dilution assay's output, the 50% infectious dose (ID50), is calculated using the Reed-Muench or Spearman-Kärber mathematical approximations, which are biased and often miscalculated. We introduce a replacement for the ID50 that we call Specific INfection (SIN) along with a free and...

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Autores principales: Daniel Cresta, Donald C Warren, Christian Quirouette, Amanda P Smith, Lindey C Lane, Amber M Smith, Catherine A A Beauchemin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/ceaf78c8923c45f0a7ea8d8aea1bad0b
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