GABAA Receptor Subunit Composition Drives Its Sensitivity to the Insecticide Fipronil

Fipronil (FPN) is a worldwide-used neurotoxic insecticide, targeting, and blocking GABAA receptors (GABAARs). Beyond its efficiency on insect GABAARs, FPN causes neurotoxic effects in humans and mammals. Here, we investigated the mode of action of FPN on mammalian α6-containing GABAARs to understand...

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Autores principales: Zineb Soualah, Antoine Taly, Lucille Crespin, Ophélie Saulais, Daniel Henrion, Claire Legendre, Hélène Tricoire-Leignel, Christian Legros, César Mattei
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/ceb9ff75ecb04493bc3f8dee993d1132
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