The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disor...

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Autores principales:	Yan Wang, Yanyan Chen, Juan Chen, Lijun Wang, Leitong Nie, Juanjuan Long, Haishuang Chang, Jian Wu, Chenhui Huang, Ming Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ceff7286fa6646f191c18e473d4322e4
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id	oai:doaj.org-article:ceff7286fa6646f191c18e473d4322e4
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spelling	oai:doaj.org-article:ceff7286fa6646f191c18e473d4322e42021-12-02T15:36:21ZThe meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope10.1038/s41467-019-08437-12041-1723https://doaj.org/article/ceff7286fa6646f191c18e473d4322e42019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08437-1https://doaj.org/toc/2041-1723The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disordered synapsis in mouse.Yan WangYanyan ChenJuan ChenLijun WangLeitong NieJuanjuan LongHaishuang ChangJian WuChenhui HuangMing LeiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Wang Yanyan Chen Juan Chen Lijun Wang Leitong Nie Juanjuan Long Haishuang Chang Jian Wu Chenhui Huang Ming Lei The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
description	The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disordered synapsis in mouse.
format	article
author	Yan Wang Yanyan Chen Juan Chen Lijun Wang Leitong Nie Juanjuan Long Haishuang Chang Jian Wu Chenhui Huang Ming Lei
author_facet	Yan Wang Yanyan Chen Juan Chen Lijun Wang Leitong Nie Juanjuan Long Haishuang Chang Jian Wu Chenhui Huang Ming Lei
author_sort	Yan Wang
title	The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
title_short	The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
title_full	The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
title_fullStr	The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
title_full_unstemmed	The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
title_sort	meiotic terb1-terb2-majin complex tethers telomeres to the nuclear envelope
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ceff7286fa6646f191c18e473d4322e4
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The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

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