IKKε isoform switching governs the immune response against EV71 infection

Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7). This study suggests that host cells trigger IKKε isoform switching to increase the production of interferon against EV71 infection, providing a...

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Autores principales:	Ya-Ling Chang, Yu-Wen Liao, Min-Hsuan Chen, Sui-Yuan Chang, Yao-Ting Huang, Bing-Ching Ho, Sung-Liang Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cf0a06bd1056452785cc2fdda4a477a3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:cf0a06bd1056452785cc2fdda4a477a32021-12-02T15:02:56ZIKKε isoform switching governs the immune response against EV71 infection10.1038/s42003-021-02187-x2399-3642https://doaj.org/article/cf0a06bd1056452785cc2fdda4a477a32021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02187-xhttps://doaj.org/toc/2399-3642Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7). This study suggests that host cells trigger IKKε isoform switching to increase the production of interferon against EV71 infection, providing a potential strategy for boosting host’s antiviral defense.Ya-Ling ChangYu-Wen LiaoMin-Hsuan ChenSui-Yuan ChangYao-Ting HuangBing-Ching HoSung-Liang YuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ya-Ling Chang Yu-Wen Liao Min-Hsuan Chen Sui-Yuan Chang Yao-Ting Huang Bing-Ching Ho Sung-Liang Yu IKKε isoform switching governs the immune response against EV71 infection
description	Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7). This study suggests that host cells trigger IKKε isoform switching to increase the production of interferon against EV71 infection, providing a potential strategy for boosting host’s antiviral defense.
format	article
author	Ya-Ling Chang Yu-Wen Liao Min-Hsuan Chen Sui-Yuan Chang Yao-Ting Huang Bing-Ching Ho Sung-Liang Yu
author_facet	Ya-Ling Chang Yu-Wen Liao Min-Hsuan Chen Sui-Yuan Chang Yao-Ting Huang Bing-Ching Ho Sung-Liang Yu
author_sort	Ya-Ling Chang
title	IKKε isoform switching governs the immune response against EV71 infection
title_short	IKKε isoform switching governs the immune response against EV71 infection
title_full	IKKε isoform switching governs the immune response against EV71 infection
title_fullStr	IKKε isoform switching governs the immune response against EV71 infection
title_full_unstemmed	IKKε isoform switching governs the immune response against EV71 infection
title_sort	ikkε isoform switching governs the immune response against ev71 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf0a06bd1056452785cc2fdda4a477a3
work_keys_str_mv	AT yalingchang ikkeisoformswitchinggovernstheimmuneresponseagainstev71infection AT yuwenliao ikkeisoformswitchinggovernstheimmuneresponseagainstev71infection AT minhsuanchen ikkeisoformswitchinggovernstheimmuneresponseagainstev71infection AT suiyuanchang ikkeisoformswitchinggovernstheimmuneresponseagainstev71infection AT yaotinghuang ikkeisoformswitchinggovernstheimmuneresponseagainstev71infection AT bingchingho ikkeisoformswitchinggovernstheimmuneresponseagainstev71infection AT sungliangyu ikkeisoformswitchinggovernstheimmuneresponseagainstev71infection
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IKKε isoform switching governs the immune response against EV71 infection

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