Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion

Orf8 is one of the most puzzling genes in the SARS lineage of coronaviruses, including SARS-CoV-2. Using sophisticated sequence comparisons, we confirm its origins from Orf7a, another gene in the lineage that appears as more conserved, compared to Orf8.

Guardado en:

Detalles Bibliográficos
Autores principales:	Russell Y. Neches, Nikos C. Kyrpides, Christos A. Ouzounis
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cf11afe1ae6e4d2fbde31a91ee8b8f81
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf11afe1ae6e4d2fbde31a91ee8b8f81
record_format	dspace
spelling	oai:doaj.org-article:cf11afe1ae6e4d2fbde31a91ee8b8f812021-11-03T18:15:38ZAtypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion2161-21292150-751110.1128/mBio.03014-20https://doaj.org/article/cf11afe1ae6e4d2fbde31a91ee8b8f812021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03014-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Orf8 is one of the most puzzling genes in the SARS lineage of coronaviruses, including SARS-CoV-2. Using sophisticated sequence comparisons, we confirm its origins from Orf7a, another gene in the lineage that appears as more conserved, compared to Orf8.Russell Y. NechesNikos C. KyrpidesChristos A. OuzounisAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Russell Y. Neches Nikos C. Kyrpides Christos A. Ouzounis Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion
description	Orf8 is one of the most puzzling genes in the SARS lineage of coronaviruses, including SARS-CoV-2. Using sophisticated sequence comparisons, we confirm its origins from Orf7a, another gene in the lineage that appears as more conserved, compared to Orf8.
format	article
author	Russell Y. Neches Nikos C. Kyrpides Christos A. Ouzounis
author_facet	Russell Y. Neches Nikos C. Kyrpides Christos A. Ouzounis
author_sort	Russell Y. Neches
title	Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion
title_short	Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion
title_full	Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion
title_fullStr	Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion
title_full_unstemmed	Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion
title_sort	atypical divergence of sars-cov-2 orf8 from orf7a within the coronavirus lineage suggests potential stealthy viral strategies in immune evasion
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/cf11afe1ae6e4d2fbde31a91ee8b8f81
work_keys_str_mv	AT russellyneches atypicaldivergenceofsarscov2orf8fromorf7awithinthecoronaviruslineagesuggestspotentialstealthyviralstrategiesinimmuneevasion AT nikosckyrpides atypicaldivergenceofsarscov2orf8fromorf7awithinthecoronaviruslineagesuggestspotentialstealthyviralstrategiesinimmuneevasion AT christosaouzounis atypicaldivergenceofsarscov2orf8fromorf7awithinthecoronaviruslineagesuggestspotentialstealthyviralstrategiesinimmuneevasion
_version_	1718445484338577408

Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion

Ejemplares similares