miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN

Although miR-related mechanisms have been implicated in nasopharyngeal carcinoma (NPC), a precise role for miR-3188 has not been reported in this context. Here, Zhao et al. show that FOXO1-induced miR-3188 acts as a tumour suppressor in NPC by regulating the axis mTOR/PI3K/Akt/c-Jun.

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Bibliographic Details
Main Authors:	Mengyang Zhao, Rongcheng Luo, Yiyi Liu, Linyuan Gao, Zhaojian Fu, Qiaofen Fu, Xiaojun Luo, Yiyu Chen, Xiaojie Deng, Zixi Liang, Xin Li, Chao Cheng, Zhen Liu, Weiyi Fang
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/cf1a67c247d14873b2bc6fa39fefc0cc
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spelling	oai:doaj.org-article:cf1a67c247d14873b2bc6fa39fefc0cc2021-12-02T16:49:43ZmiR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN10.1038/ncomms113092041-1723https://doaj.org/article/cf1a67c247d14873b2bc6fa39fefc0cc2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11309https://doaj.org/toc/2041-1723Although miR-related mechanisms have been implicated in nasopharyngeal carcinoma (NPC), a precise role for miR-3188 has not been reported in this context. Here, Zhao et al. show that FOXO1-induced miR-3188 acts as a tumour suppressor in NPC by regulating the axis mTOR/PI3K/Akt/c-Jun.Mengyang ZhaoRongcheng LuoYiyi LiuLinyuan GaoZhaojian FuQiaofen FuXiaojun LuoYiyu ChenXiaojie DengZixi LiangXin LiChao ChengZhen LiuWeiyi FangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mengyang Zhao Rongcheng Luo Yiyi Liu Linyuan Gao Zhaojian Fu Qiaofen Fu Xiaojun Luo Yiyu Chen Xiaojie Deng Zixi Liang Xin Li Chao Cheng Zhen Liu Weiyi Fang miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
description	Although miR-related mechanisms have been implicated in nasopharyngeal carcinoma (NPC), a precise role for miR-3188 has not been reported in this context. Here, Zhao et al. show that FOXO1-induced miR-3188 acts as a tumour suppressor in NPC by regulating the axis mTOR/PI3K/Akt/c-Jun.
format	article
author	Mengyang Zhao Rongcheng Luo Yiyi Liu Linyuan Gao Zhaojian Fu Qiaofen Fu Xiaojun Luo Yiyu Chen Xiaojie Deng Zixi Liang Xin Li Chao Cheng Zhen Liu Weiyi Fang
author_facet	Mengyang Zhao Rongcheng Luo Yiyi Liu Linyuan Gao Zhaojian Fu Qiaofen Fu Xiaojun Luo Yiyu Chen Xiaojie Deng Zixi Liang Xin Li Chao Cheng Zhen Liu Weiyi Fang
author_sort	Mengyang Zhao
title	miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
title_short	miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
title_full	miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
title_fullStr	miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
title_full_unstemmed	miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
title_sort	mir-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a foxo1-modulated positive feedback loop with mtor–p-pi3k/akt-c-jun
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cf1a67c247d14873b2bc6fa39fefc0cc
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miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN

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