Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells

Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells

Per-O-acetylated unnatural monosaccharides are popular tools for glycan labeling in live cells but can undergo unwanted side reactions with cysteines. Here, the authors develop unnatural sugars in a partially esterified form that are inert towards cysteines, and use them to probe O-GlcNAcylation in...

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Autores principales: Yi Hao, Xinqi Fan, Yujie Shi, Che Zhang, De-en Sun, Ke Qin, Wei Qin, Wen Zhou, Xing Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cf360d76d7754dd9bc90b461c1601791
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spelling oai:doaj.org-article:cf360d76d7754dd9bc90b461c16017912021-12-02T15:35:03ZNext-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells10.1038/s41467-019-11942-y2041-1723https://doaj.org/article/cf360d76d7754dd9bc90b461c16017912019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11942-yhttps://doaj.org/toc/2041-1723Per-O-acetylated unnatural monosaccharides are popular tools for glycan labeling in live cells but can undergo unwanted side reactions with cysteines. Here, the authors develop unnatural sugars in a partially esterified form that are inert towards cysteines, and use them to probe O-GlcNAcylation in mESCs.Yi HaoXinqi FanYujie ShiChe ZhangDe-en SunKe QinWei QinWen ZhouXing ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yi Hao
Xinqi Fan
Yujie Shi
Che Zhang
De-en Sun
Ke Qin
Wei Qin
Wen Zhou
Xing Chen
Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells
description Per-O-acetylated unnatural monosaccharides are popular tools for glycan labeling in live cells but can undergo unwanted side reactions with cysteines. Here, the authors develop unnatural sugars in a partially esterified form that are inert towards cysteines, and use them to probe O-GlcNAcylation in mESCs.
format article
author Yi Hao
Xinqi Fan
Yujie Shi
Che Zhang
De-en Sun
Ke Qin
Wei Qin
Wen Zhou
Xing Chen
author_facet Yi Hao
Xinqi Fan
Yujie Shi
Che Zhang
De-en Sun
Ke Qin
Wei Qin
Wen Zhou
Xing Chen
author_sort Yi Hao
title Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells
title_short Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells
title_full Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells
title_fullStr Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells
title_full_unstemmed Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells
title_sort next-generation unnatural monosaccharides reveal that esrrb o-glcnacylation regulates pluripotency of mouse embryonic stem cells
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/cf360d76d7754dd9bc90b461c1601791
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