SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and prote...

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Autores principales: Julie Rageul, Jennifer J. Park, Ping Ping Zeng, Eun-A Lee, Jihyeon Yang, Sunyoung Hwang, Natalie Lo, Alexandra S. Weinheimer, Orlando D. Schärer, Jung-Eun Yeo, Hyungjin Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cf4354514492419cabdbc66606aed2dc
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