SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and prote...

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Autores principales:	Julie Rageul, Jennifer J. Park, Ping Ping Zeng, Eun-A Lee, Jihyeon Yang, Sunyoung Hwang, Natalie Lo, Alexandra S. Weinheimer, Orlando D. Schärer, Jung-Eun Yeo, Hyungjin Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf4354514492419cabdbc66606aed2dc
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spelling	oai:doaj.org-article:cf4354514492419cabdbc66606aed2dc2021-12-02T17:31:56ZSDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks10.1038/s41467-020-19162-52041-1723https://doaj.org/article/cf4354514492419cabdbc66606aed2dc2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19162-5https://doaj.org/toc/2041-1723The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and protecting stalled forks by regulating the replication fork protection complex (FPC).Julie RageulJennifer J. ParkPing Ping ZengEun-A LeeJihyeon YangSunyoung HwangNatalie LoAlexandra S. WeinheimerOrlando D. SchärerJung-Eun YeoHyungjin KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julie Rageul Jennifer J. Park Ping Ping Zeng Eun-A Lee Jihyeon Yang Sunyoung Hwang Natalie Lo Alexandra S. Weinheimer Orlando D. Schärer Jung-Eun Yeo Hyungjin Kim SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
description	The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and protecting stalled forks by regulating the replication fork protection complex (FPC).
format	article
author	Julie Rageul Jennifer J. Park Ping Ping Zeng Eun-A Lee Jihyeon Yang Sunyoung Hwang Natalie Lo Alexandra S. Weinheimer Orlando D. Schärer Jung-Eun Yeo Hyungjin Kim
author_facet	Julie Rageul Jennifer J. Park Ping Ping Zeng Eun-A Lee Jihyeon Yang Sunyoung Hwang Natalie Lo Alexandra S. Weinheimer Orlando D. Schärer Jung-Eun Yeo Hyungjin Kim
author_sort	Julie Rageul
title	SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
title_short	SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
title_full	SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
title_fullStr	SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
title_full_unstemmed	SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
title_sort	sde2 integrates into the timeless-tipin complex to protect stalled replication forks
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cf4354514492419cabdbc66606aed2dc
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SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

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