Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

Aerolysin is a secreted bacterial pore forming toxin that inserts into the host plasma membrane, potentially leading to cell death. Here the authors present Cryo-EM structures of aerolysin arrested at different stages of the pore formation process that provide insight into the conformational changes...

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Autores principales: Ioan Iacovache, Sacha De Carlo, Nuria Cirauqui, Matteo Dal Peraro, F. Gisou van der Goot, Benoît Zuber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/cf673eee03eb4a2b9b6bf3aad1ad1011
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