Joint mouse–human phenome-wide association to test gene function and disease risk
Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to corresponding PheWAS in human.
Saved in:
| Main Authors: | Xusheng Wang, Ashutosh K. Pandey, Megan K. Mulligan, Evan G. Williams, Khyobeni Mozhui, Zhengsheng Li, Virginija Jovaisaite, L. Darryl Quarles, Zhousheng Xiao, Jinsong Huang, John A. Capra, Zugen Chen, William L. Taylor, Lisa Bastarache, Xinnan Niu, Katherine S. Pollard, Daniel C. Ciobanu, Alexander O. Reznik, Artem V. Tishkov, Igor B. Zhulin, Junmin Peng, Stanley F. Nelson, Joshua C. Denny, Johan Auwerx, Lu Lu, Robert W. Williams |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2016
|
| Subjects: | |
| Online Access: | https://doaj.org/article/cfc59303336541d2b8ee796f1a6ebb5b |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Multi-omic characterization of the thermal stress phenome in the stony coral Montipora capitata
by: Amanda Williams, et al.
Published: (2021) -
The complete genome and phenome of a community-acquired Acinetobacter baumannii.
by: Daniel N Farrugia, et al.
Published: (2013) -
Phenomics: A Way to Increase and Refine Treatment Options in Psychopathology
by: Mauricio Cuartas-Arias
Published: (2021) -
Predicting quantitative traits from genome and phenome with near perfect accuracy
by: Kaspar Märtens, et al.
Published: (2016) -
Humanized GPRC6A KGKY is a gain-of-function polymorphism in mice
by: Min Pi, et al.
Published: (2020)