Joint mouse–human phenome-wide association to test gene function and disease risk

Joint mouse–human phenome-wide association to test gene function and disease risk

Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to corresponding PheWAS in human.

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Bibliographic Details
Main Authors: Xusheng Wang, Ashutosh K. Pandey, Megan K. Mulligan, Evan G. Williams, Khyobeni Mozhui, Zhengsheng Li, Virginija Jovaisaite, L. Darryl Quarles, Zhousheng Xiao, Jinsong Huang, John A. Capra, Zugen Chen, William L. Taylor, Lisa Bastarache, Xinnan Niu, Katherine S. Pollard, Daniel C. Ciobanu, Alexander O. Reznik, Artem V. Tishkov, Igor B. Zhulin, Junmin Peng, Stanley F. Nelson, Joshua C. Denny, Johan Auwerx, Lu Lu, Robert W. Williams
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/cfc59303336541d2b8ee796f1a6ebb5b
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Internet

https://doaj.org/article/cfc59303336541d2b8ee796f1a6ebb5b

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