UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair

R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role in promoting R loops formation at telomeric d...

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Autores principales: Greg H. P. Ngo, Julia W. Grimstead, Duncan M. Baird
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/cfce330374694ea4bad27a13a3243c22
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