UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair

R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role in promoting R loops formation at telomeric d...

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Autores principales:	Greg H. P. Ngo, Julia W. Grimstead, Duncan M. Baird
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cfce330374694ea4bad27a13a3243c22
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id	oai:doaj.org-article:cfce330374694ea4bad27a13a3243c22
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spelling	oai:doaj.org-article:cfce330374694ea4bad27a13a3243c222021-12-02T17:44:52ZUPF1 promotes the formation of R loops to stimulate DNA double-strand break repair10.1038/s41467-021-24201-w2041-1723https://doaj.org/article/cfce330374694ea4bad27a13a3243c222021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24201-whttps://doaj.org/toc/2041-1723R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role in promoting R loops formation at telomeric double strand breaks to stimulate DNA resection and repair.Greg H. P. NgoJulia W. GrimsteadDuncan M. BairdNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Greg H. P. Ngo Julia W. Grimstead Duncan M. Baird UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
description	R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role in promoting R loops formation at telomeric double strand breaks to stimulate DNA resection and repair.
format	article
author	Greg H. P. Ngo Julia W. Grimstead Duncan M. Baird
author_facet	Greg H. P. Ngo Julia W. Grimstead Duncan M. Baird
author_sort	Greg H. P. Ngo
title	UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
title_short	UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
title_full	UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
title_fullStr	UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
title_full_unstemmed	UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
title_sort	upf1 promotes the formation of r loops to stimulate dna double-strand break repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cfce330374694ea4bad27a13a3243c22
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UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair

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