An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β

Abstract A key hallmark of Alzheimer’s disease is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein, the first step of which gives rise to a C-terminal Fr...

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Autores principales: Devkee M. Vadukul, Céline Vrancx, Pierre Burguet, Sabrina Contino, Nuria Suelves, Louise C. Serpell, Loïc Quinton, Pascal Kienlen-Campard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/cffde72cfd7a458c9a29c038453f9d37
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