Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination

Biologically active compounds often contain a chiral centre in proximity of amine groups. Here, the authors developed a strategy involving asymmetric isomerization of allylic amines, enamine exchange and chemoselective reduction for the one-pot highly enantioselective synthesis of gamma-branched ami...

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Autores principales: Zhao Wu, Summer D. Laffoon, Kami L. Hull
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d0056dab2aed43fea5991c0676edf1b0
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