Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination

Biologically active compounds often contain a chiral centre in proximity of amine groups. Here, the authors developed a strategy involving asymmetric isomerization of allylic amines, enamine exchange and chemoselective reduction for the one-pot highly enantioselective synthesis of gamma-branched ami...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhao Wu, Summer D. Laffoon, Kami L. Hull
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0056dab2aed43fea5991c0676edf1b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0056dab2aed43fea5991c0676edf1b0
record_format	dspace
spelling	oai:doaj.org-article:d0056dab2aed43fea5991c0676edf1b02021-12-02T14:39:44ZAsymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination10.1038/s41467-018-03535-y2041-1723https://doaj.org/article/d0056dab2aed43fea5991c0676edf1b02018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03535-yhttps://doaj.org/toc/2041-1723Biologically active compounds often contain a chiral centre in proximity of amine groups. Here, the authors developed a strategy involving asymmetric isomerization of allylic amines, enamine exchange and chemoselective reduction for the one-pot highly enantioselective synthesis of gamma-branched amines.Zhao WuSummer D. LaffoonKami L. HullNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhao Wu Summer D. Laffoon Kami L. Hull Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
description	Biologically active compounds often contain a chiral centre in proximity of amine groups. Here, the authors developed a strategy involving asymmetric isomerization of allylic amines, enamine exchange and chemoselective reduction for the one-pot highly enantioselective synthesis of gamma-branched amines.
format	article
author	Zhao Wu Summer D. Laffoon Kami L. Hull
author_facet	Zhao Wu Summer D. Laffoon Kami L. Hull
author_sort	Zhao Wu
title	Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
title_short	Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
title_full	Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
title_fullStr	Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
title_full_unstemmed	Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
title_sort	asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d0056dab2aed43fea5991c0676edf1b0
work_keys_str_mv	AT zhaowu asymmetricsynthesisofgbranchedaminesviarhodiumcatalyzedreductiveamination AT summerdlaffoon asymmetricsynthesisofgbranchedaminesviarhodiumcatalyzedreductiveamination AT kamilhull asymmetricsynthesisofgbranchedaminesviarhodiumcatalyzedreductiveamination
_version_	1718390560196132864

Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination

Ejemplares similares