A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus

A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus

ABSTRACT In this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism allows for systemic infection of chickens, ducks, and mice, and A/Mdk/6L/07 can re...

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Bibliographic Details
Main Authors: Hyeok-il Kwon, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Semi Kim, Young-Jae Si, Min-Suk Song, Philippe Noriel Q. Pascua, Elena A. Govorkova, Robert G. Webster, Richard J. Webby, Young Ki Choi
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
H7
N6 neuraminidase
thrombin-like protease
GRG motif
trypsin-independent growth
influenza
Microbiology
QR1-502
Online Access:https://doaj.org/article/d01f741f62bf4fb48865c8cb4b0e7d96
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https://doaj.org/article/d01f741f62bf4fb48865c8cb4b0e7d96

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