Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors

Abstract In atherosclerotic lesions, blood-derived monocytes differentiate into distinct macrophage subpopulations, and further into cholesterol-filled foam cells under a complex milieu of cytokines, which also contains macrophage-colony stimulating factor (M-CSF) and granulocyte–macrophage-colony s...

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Autores principales: Jani Lappalainen, Nicolas Yeung, Su D. Nguyen, Matti Jauhiainen, Petri T. Kovanen, Miriam Lee-Rueckert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d024a2c8f799481abd06e448627a9d01
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