Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition

Natural killer (NK) cells eliminate damaged cells, but spare healthy ones by recognizing their expressed ligands via NK inhibitory receptors. Here the authors solve the structure of an NK inhibitory receptor, NKR-P1B, bound to its ligand, Clr-b, with further data suggesting a weak interaction and in...

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Autores principales:	Gautham R. Balaji, Oscar A. Aguilar, Miho Tanaka, Miguel A. Shingu-Vazquez, Zhihui Fu, Benjamin S. Gully, Lewis L. Lanier, James R. Carlyle, Jamie Rossjohn, Richard Berry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0281b6f4ebc43a183d59a0c42bc49bc
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spelling	oai:doaj.org-article:d0281b6f4ebc43a183d59a0c42bc49bc2021-12-02T15:33:59ZRecognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition10.1038/s41467-018-06989-22041-1723https://doaj.org/article/d0281b6f4ebc43a183d59a0c42bc49bc2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06989-2https://doaj.org/toc/2041-1723Natural killer (NK) cells eliminate damaged cells, but spare healthy ones by recognizing their expressed ligands via NK inhibitory receptors. Here the authors solve the structure of an NK inhibitory receptor, NKR-P1B, bound to its ligand, Clr-b, with further data suggesting a weak interaction and informing on the basis of missing-self recognition.Gautham R. BalajiOscar A. AguilarMiho TanakaMiguel A. Shingu-VazquezZhihui FuBenjamin S. GullyLewis L. LanierJames R. CarlyleJamie RossjohnRichard BerryNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gautham R. Balaji Oscar A. Aguilar Miho Tanaka Miguel A. Shingu-Vazquez Zhihui Fu Benjamin S. Gully Lewis L. Lanier James R. Carlyle Jamie Rossjohn Richard Berry Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
description	Natural killer (NK) cells eliminate damaged cells, but spare healthy ones by recognizing their expressed ligands via NK inhibitory receptors. Here the authors solve the structure of an NK inhibitory receptor, NKR-P1B, bound to its ligand, Clr-b, with further data suggesting a weak interaction and informing on the basis of missing-self recognition.
format	article
author	Gautham R. Balaji Oscar A. Aguilar Miho Tanaka Miguel A. Shingu-Vazquez Zhihui Fu Benjamin S. Gully Lewis L. Lanier James R. Carlyle Jamie Rossjohn Richard Berry
author_facet	Gautham R. Balaji Oscar A. Aguilar Miho Tanaka Miguel A. Shingu-Vazquez Zhihui Fu Benjamin S. Gully Lewis L. Lanier James R. Carlyle Jamie Rossjohn Richard Berry
author_sort	Gautham R. Balaji
title	Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
title_short	Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
title_full	Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
title_fullStr	Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
title_full_unstemmed	Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
title_sort	recognition of host clr-b by the inhibitory nkr-p1b receptor provides a basis for missing-self recognition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d0281b6f4ebc43a183d59a0c42bc49bc
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Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition

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