Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition

Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition

Natural killer (NK) cells eliminate damaged cells, but spare healthy ones by recognizing their expressed ligands via NK inhibitory receptors. Here the authors solve the structure of an NK inhibitory receptor, NKR-P1B, bound to its ligand, Clr-b, with further data suggesting a weak interaction and in...

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Bibliographic Details
Main Authors: Gautham R. Balaji, Oscar A. Aguilar, Miho Tanaka, Miguel A. Shingu-Vazquez, Zhihui Fu, Benjamin S. Gully, Lewis L. Lanier, James R. Carlyle, Jamie Rossjohn, Richard Berry
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/d0281b6f4ebc43a183d59a0c42bc49bc
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