Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation

Abstract The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steric effect of relatively large fluorescence tags and...

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Auteurs principaux: Sivan Peled, Dorin Sade, Yaron Bram, Ziv Porat, Topaz Kreiser, Michael Mimouni, Alexandra Lichtenstein, Daniel Segal, Ehud Gazit
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/d049f33829294b88ae864baa009409c9
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