Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.

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Auteurs principaux: Annie M. Sriramachandran, Katrin Meyer-Teschendorf, Stefan Pabst, Helle D. Ulrich, Niels H. Gehring, Kay Hofmann, Gerrit J. K. Praefcke, R. Jürgen Dohmen
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/d0762ab2824541ce8ce0b7085be1b113
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